A modern nuke is FAR from the “bang 2 rocks together” designs that were first designed. For a start, most are fusion devices. Fairly exotic reactions are used to make a small amount of fusion material to go critical. This creates a shaped charge on a fusion core. The compression wave sets fusion happening, which releases 95% of the energy. Most of Russia’s arsenal is of this sort.
The downsides of these is the use of exotic elements. They often have a short half life, e.g. tritium, with 12.5 years. This means they decay. Even worse, some of the byproducts will actually poison the reaction. E.g. Rather than producing a flood of neutrons, they absorb them.
If any of this chain fails, then your fusion nuke becomes, at best, a low yield fission nuke. More likely, it becomes a dirty bomb. It’s still nasty, but not the city destroying terror weapon it would be intended as.
Hey, at least drugs will now be lacklustre, and unforfilling. The factory must grow to meet the demands of the expanding factory!